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Auto hemolysis Test |
| Test | Auto hemolysis Test |
| Indication | This test is used to diagnose hereditary spherocytosis, spontaneous hemolysis, RBC enzyme deficiency and hemolytic anemia. |
| Physiology | This test measures the degree to which patients red cells lyse without additives, with glucose and with ATP (Adenosine Tri-phosphate). |
| Interpretation | Glucose by itself can induce hemolysis in auto hemolysis test in patients with hereditary spherocytosis. Glucose-6-Phosphate dehydrogenase deficient RBC’s have increased auto hemolysis, which corrects significantly with glucose or ATP. Pyruvatekinase deficiency has increased auto-hemolysis, which does not correct or get aggravated with glucose but does correct toward normal with ATP. |
| Related Tests | Glucose-6-Phosphate dehydrogenase Osmotic Fragility, Red Blood Cell Morphology, RBC enzyme deficiency. |
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